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Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property.

Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization.

• Provides a comprehensive and valuable working handbook for scientists and students in medicinal chemistry
• Includes expanded coverage of pharmacokinetics fundamentals and effects
• Contains updates throughout, including the authors’ recent work in the importance of solubility in drug development; new and currently used property methods, with a reduction of seldom-used methods; and exploration of computational modeling methods

• Sales Rank: #1239604 in Books
• Published on: 2016-01-27
• Original language: English
• Number of items: 1
• Dimensions: 10.90" h x 1.30" w x 8.60" l, 3.65 pounds
• Binding: Hardcover
• 580 pages

About the Author
Li Di is an Associate Research Fellow at Pfizer, USA

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Drug-Like Properties, Second Edition: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, by Li Di, Edward H Kerns PDF

Drug-Like Properties, Second Edition: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, by Li Di, Edward H Kerns PDF

[N771.Ebook] Ebook The Consultant's Handbook: A Practical Guide to Delivering High-value and Differentiated Services in a Competitive Marketplace, by Samir P

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Delivers the essential practical skills needed to consult and make sharp, well prepared interactions in a wide range of business situations

This comprehensive handbook covers the fundamental skills and attitudes required by successful consultants from novice to practitioner level, irrespective of their specialist area. It untangles the key variables present in any consulting service and introduces practical ways to improve their effectiveness based upon the author's experience of helping consulting organisations to develop and excel in the marketplace. The book explores consulting ‘from the ground up' steering away from theory and focusing instead on practical application, providing a solid platform upon which to build further domain-specific competence.

The Consultant's Handbook provides:

• An understanding of the key variables that can be addressed in order to improve one's own consulting performance
• A set of simple practices that can be implemented with immediate benefit to the reader
• Practical insight into day-to-day real life consulting interactions
• Confidence to implement the new ideas and approaches

• Sales Rank: #647039 in Books
• Published on: 2015-07-20
• Original language: English
• Number of items: 1
• Dimensions: 9.30" h x .90" w x 6.25" l, 1.00 pounds
• Binding: Hardcover
• 232 pages

Review

“It’s a clearly-presented book that’s clearly applicable to public relations consultants… I’m placing [it] on my bookshelf alongside the classic texts on consulting by David Maister” (Behind the Spin, June 2015)

“Enough good material here to interest those embarking on this career path” (The Irish Times, July 2015)

From the Inside Flap

'This is a must-read book for anyone who is thinking of embarking on a career as a consultant. Samir Parikh has many years of experience in this field, and he has distilled this down into a wealth of reflections and practical advice'
—JULIAN BIRKINSHAW, Professor, London Business School

'Samir Parikh is sharing proven consulting practices and a solid approach for client engagement. Anyone who has the ambition to engage clients using a consultative approach will derive great value from this work, in particular from the wealth of real-life examples'
—CHRISTER JOHANSSON, Senior Competence Management Expert, SKF Group

'Samir has inspired culturally diverse audiences of varying seniority by sharing valuable lessons from his own extensive experience around the globe. He provides practical ideas that can be applied immediately in an everyday work context and these are now encapsulated in The Consultant's Handbook'
—OLA PETTERSSON, Head of Technology Consulting, Ericsson

From the Back Cover

AN INDISPENSABLE GUIDE TO CONSULTING WITH CONFIDENCE

Consulting is becoming an increasingly critical function in today's organizations, where expert knowledge translates into competitive advantage. The Consultant's Handbook introduces the essential practical skills required to consult and make sharp, well-prepared interactions in a wide range of business situations.

Based upon his 20 years of experience in international consulting, Samir Parikh outlines a set of simple practices that you can apply straight away.

LEARN HOW TO:

• Prepare for a successful consulting engagement
• Establish suitable credibility as a consultant
• Manage client projects and interactions effectively
• Overcome client-related obstacles
• Formulate and deliver compelling arguments and advice

With extensive case studies providing insight into the day-to-day requirements for consulting and actionable tips throughout, you will gain an understanding of the fundamental skills and attitudes needed to excel in the world of consulting.

Most helpful customer reviews

5 of 5 people found the following review helpful.
An essential practical reference on consulting
By Pablo Infantino
I had the pleasure of taking a consulting course taught by Samir Parikh 14 years ago. To this day, this course remains the single most influential training experience in my career. So it was with great anticipation that I read "The Consultant's Handbook", and I was not disappointed. The book's title sums it up; if I had to choose just one practical reference source on consulting, this would be the one.

0 of 0 people found the following review helpful.
Clear and practical guide for consultants
By Emily Tarrant
This book is a breath of fresh air. It’s a book which is exactly what it says it is – a handbook for consultants. It takes you through different elements of offering a consulting service, clearly explaining what’s needed and giving examples to help you fully understand the points made.

What struck me is that the advice in the book is all highly practical – it doesn’t just set out high level theory as to what a consultant is but really gets into the nitty gritty of it. For example there’s a chapter on Managing Client Meetings which takes you through how to plan the meeting and suggesting how to structure the meeting to get the best results. This is a level of detail which I often feel is missing from business books.

Although the examples in the book are from scenarios involving large businesses, I could easily see how I could apply a lot of the techniques and structure to working on small projects. The client meetings section is one that particularly jumped out at me and I will be going through that again to feed into how we run meetings. Another area which really struck a cord with me is the importance of good communication in project work. This is an area which I always feel I need to improve, so I will be dipping back into this as well.

And I really do feel like this is a book which I will be able to ‘dip’ back into to pull out particular information, which is exactly what you need with a handbook. I love the way the chapters are laid out, with regular sub-headings to give each a really strong structure, the examples boxed out to differentiate from the rest of the content, and a summary at the end reiterating the important points. My tidy brain really appreciated the structured approach.

I think you can probably tell by now that I’m a big fan of this book. More of the same please!

0 of 0 people found the following review helpful.
Five Stars
By Faris
Easy to read. Very insightful. Invaluable reference to someone who wants to develop consultative skills besides their existing competencies.

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All you need to create your own great hair style at home!

Vetica preaches that professional techniques are not difficult; readers just need to know what to do and follow directions. In this ultimate hair styling book, he delivers to the reader all they need to know to create great hair at home or direct a professional stylist. He reveals insider secrets and techniques for recreating magazine and celebrity hairstyles, and how to adapt the look for the average reader’s tools and time constraints.

The book is divided into three parts; 1. hair treatment and care, 2. hair cutting and styling techniques and 3. how to find a look for your faces structure and personal style. Even beginners will be able to style their hair like a pro while professional stylists can fine tune their skills with Vetica’s secrets and shortcuts. Step-by-step diagrams and photos illustrate different styles and how to work with tools of the trade such as curling irons, hair clips, and blow dryers. Before-and-after photos show readers the best hairstyles based on face shape, bone structure, type of hair, age, and personal style. Vetica peppers all of the techniques with his experience and insights gained from working with Hollywood’s top celebrities.

• Sales Rank: #12857376 in Books
• Brand: Brand: Apple Press
• Published on: 2009
• Original language: English
• Number of items: 1
• Dimensions: 7.99" h x .75" w x 10.00" l, 2.48 pounds
• Binding: Paperback

Features

• Used Book in Good Condition

Review
Vetica, Robert. Good to Great Hair: Celebrity Hairstyling Techniques Made Simple. Fair Winds: Quayside. 2009. 272p. photogs. ISBN 978-1-59233-357-8. pap. $24.99. PERSONAL GROOMING

Marie Claire Hair and Good to Great Hair both provide innovative hair designs and insights from top stylists in beautifully designed texts. Of the two, Vetica’s book is more accessible and truly delivers clear, step-by-step instructions. Vetica has more than 30 years of experience, including a roster of celebrity beauty and fashion icons as clients. While a bit heavy on autobiography, his book includes makeovers for women of various ages and hair types and translates high glamour and special-event hairstyles for nonprofessionals. Though it includes quick, general tips about hair care and style, Milgram’s book seems more appropriate for professionals and is only recommended for special collections or for large public libraries where similar titles circulate widely. Good to Great, on the other hand, is suitable for a general audience owing to its celebrity appeal and more practical approach. --Library Journal, Feb 15, 2009

Most helpful customer reviews

8 of 8 people found the following review helpful.
NOT WHAT IT SEEMS
By chrisicut
my daughter wanted a book on how to style hair, this book is great for teaching the basics of care and a right cut but not styling. it gave the impression it "showed" how to style your own hair when infact the pictures are of someone else doing the styles on a model. wanting a book with pictures of that individual actually fixing their own hair so show placement of hands and equipment when used.

1 of 1 people found the following review helpful.
It's OK but Eva Scrivo on Beauty blows it out of the water!
By overtakenbyanap
I bought this on my kindle and have had it a few years now, I got a few tips from it but not much. The detailed lists of products are helpful but he isn't as helpful when it comes to cuts that you can take a picture of to your hairdresser (or open your kindle and show them).

This reads more like a celebrity hairdresser (which he is) dishing on what he did for this or that woman's hair.

Eva Scrivo does all that and more.

0 of 0 people found the following review helpful.
Great book with useful tips and advice
By MsScarlett
This book had lots of great tips for styling hair and keeping it healthy. It was also well written, especially given that the stylist is not a professional writer. The photos and quality of the book are also very good. I got lots of great tips from this book that I use every day.

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In her compendious study, [of the folktale of the runaway wife] Leavy argues that the contradictory claims of nature and culture are embodied in the legendary figure of the swan maiden, a woman torn between the human and bestial worlds.
--The New York Times Book Review

This is a study of the meaning of gender as framed by the swan maiden tale, a story found in the folklore of virtually every culture. The swan maiden is a supernatural woman forced to marry, keep house, and bear children for a mortal man who holds the key to her imprisonment. When she manages to regain this key, she escapes to the otherworld, never to return.

These tales have most often been interpreted as depicting exogamous marriages, describing the girl from another tribe trapped in a world where she will always be the outsider. Barbara Fass Leavy believes that, in the societies in which the tale and its variants endured, woman was the other--the outsider trapped in a society that could never be her own. Leavy shows how the tale, though rarely explicitly recognized, is frequently replayed in modern literature.

Beautifully written, this book reveals the myriad ways in which the folktales of a society reflect its cultural values, and particularly how folktales are allegories of gender relations. It will interest anyone involved in literary, gender, and cultural studies.

• Sales Rank: #816484 in Books
• Brand: Brand: NYU Press
• Published on: 1995-07-01
• Released on: 1995-07-01
• Original language: English
• Number of items: 1
• Dimensions: 9.02" h x .86" w x 5.98" l, 1.15 pounds
• Binding: Paperback
• 388 pages

Features

• Used Book in Good Condition

Review

"A consistently clear, comprehensive and accessible introduction which carefully sifts Foucault's work for both its strengths and weaknesses. McHoul and Grace show an intimate familiarity with Foucault's writings and a lively, but critical engagement with the relevance of his work. A model primer."
-Tony Bennett, author of "Outside Literature"

About the Author

Barbara Fass Leavy is Professor of English at Queens College, City University of New York and Adjunct Professor of English in Psychiatry at Cornell University Medical College. She is the author of To Blight with Plague: Studies in a Literary Theme and, with Per Schelde Jacobsen, of Ibsen's Forsaken Merman: Folklore in the Late Plays.

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• Sales Rank: #5757253 in Books
• Published on: 2014-02-01
• Dimensions: .42 pounds
• Binding: Paperback
• 168 pages

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The story of the declaration of independence.

• Sales Rank: #2064539 in Books
• Published on: 2001
• Number of items: 1
• Binding: Paperback
• 90 pages

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Level 3. This book features some of the most disgusting, far-out bugs on the planet. Learn how a scorpion uses its poison, discover how the jumping spider hunts, and more!

• Sales Rank: #132525 in Books
• Brand: Penguin Young Readers
• Published on: 2007-05-10
• Released on: 2007-05-10
• Original language: English
• Number of items: 1
• Dimensions: 9.00" h x .13" w x 6.00" l, .26 pounds
• Binding: Paperback
• 48 pages

About the Author
Ginjer L. Clarke lives in Richmond, Virginia. Pete Mueller lives in Portsmouth, Rhode Island.

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All for Bug Out!
By A Customer
Bug Out! brings bugs to life as Mrs.Clarke writes about these fascinating
creatures. It is a fantastic mix between scientific facts and a clear, easy-to-read text, giving you a book full of cool, disgusting, and intriguing bugs - just right for young readers. - Andrew Age 8TURBO BUG VACBackyard Safari Bug VacuumButterfly House (Bug Cage)Backyard Safari Butterfly Habitat

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Excellent!
By Abigail Fox
My son does not particularly enjoy reading himself, but this book series is one that he happily read. I highly recommend for any child that is interested in animals and some of the gross and interesting things that they do. We went to the zoo after reading this series too and my son had a ball seeing some of the animals from this series. He thinks these books are cool.

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It is a great book to get younger readers reading
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My grandson is 6 years old and loves to read these book. He loves animals and will read these books over and over. It is a great book to get younger readers reading.

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